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新产品编号:2093495

Chemical Name: 1-Acetyl-3-benzyl-5-methyl-2-thioxoimidazolidin-4-one
项目整合开发状态: Preclinical
项目研究机构: National Institutes of Health (Originator), University of Houston (Originator), University of North Carolina (Originator)
合成路线:Condensation of alanine methyl ester (I) with benzyl isothiocyanate (II) in the presence of Et3N produced the thiohydantoin (III).This was further acetylated by means of acetic anhydride and DMAP to yield the title compound.
📌 参考资料/链接:
参考文献标题:Functionalized amino acid anticonvulsants: Synthesis and pharmacological evaluation of conformationally restricted analogues
文献作者:Le Tiran,A.; Stables,J.P.; Kohn,H.
参考来源:Bioorg Med Chem 2001,9(10),2693