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新产品编号:2088749

Chemical Name: 9-[2-[[2(Z)-(3,4-Dimethoxy-5-oxo-2,5-dihydrofuran-2-ylidene)ethoxy](hydroxy)phosphorylmethoxy]ethyl]adenine; [2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid 2(Z)-(3,4-dimethoxy-5-oxo-2,5-dihydrofuran-2-ylidene)ethyl ester
项目整合开发状态: Preclinical
项目研究机构: Academia Sinica (Originator), China Medical College (Originator), Purdue University (Originator), Shiraz University (Originator), University of Tehran (Originator)
合成路线:The condensation of 9-[2-(phosphonomethoxy)ethyl]adenine (I) with butenolide (II) by means of NaHCO3 in hot DMF gives the target phosphonate monoester.
📌 参考资料/链接:
参考文献标题:Design,synthesis,and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses
文献作者:Hakimelahi,G.H.; Ly,T.W.; Moosavi-Movahedi,A.A.; Jain,M.L.; Zakerinia,M.; Davari,H.; Mei,H.C.; Sambaiah,T.; Moshfegh,A.A.; Hakimelahi,S.
参考来源:J Med Chem 2001,44(22),3710