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新产品编号:2085585

Chemical Name: 1-(2-Phenylethyl)-2-(2-propynyl)hydrazine
项目整合开发状态: Preclinical
项目研究机构: CV Technologies (Originator)
合成路线:The condensation of 2-phenylethylhydrazine (I) with propargyl bromide (II) by means of K2CO3 in aqueous acetonitrile gives the target hydrazine.

合成路线:The condensation of fully Boc-protected 2-phenylethylhydrazine (I) with propargyl bromide (II) by means of NaH gives the protected disubstituted hydrazine (III),which is finally deprotected with 4N HCl in dioxane to afford the target hydrazine.
📌 参考资料/链接:
参考文献标题:Synthesis of N-propargylphenelzine and analogues as neuroprotective agents
文献作者:Ling,L.; Urichuk,L.J.; Sloley,B.D.; Coutts,R.T.; Baker,G.B.; Shan,J.J.; Pang,P.K.T.
参考来源:Bioorg Med Chem Lett 2001,11(20),2715