KPN-2001

Chemical Name: (3R,3aR,5aS,5bR,8S,9aR,10R,10aS,10bS)-3-[1(R),5-Dimethylhexyl]-8,9a-dihydroxy-3a,5b-dimethylperhydrocyclopenta[a]fluorene-10-carbaldehyde
项目整合开发状态: Biological Testing
项目研究机构: Kyushu University (Originator), University of Amsterdam (Originator)
合成路线:Ozonolysis of cholesterol (I) in Et2O at -78 C,followed by reductive treatment of the intermediate ozonide with dimethyl sulfide,produced the keto aldehyde cleaved compound (II).Intramolecular aldol condensation of (II) in the presence of LDA in cold THF furnished the title sterol.