新产品编号:2058691
Chemical Name: N-[N-[5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxyphenyl]sulfamoyl]carbamic acid dodecyl ester
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Condensation of dodecanol (I) with chlorosulfonyl isocyanate in the presence of triethylamine afforded the chlorosulfonyl carbamate (II).Without isolation,sulfonyl chloride (II) was condensed with 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxyaniline (III) to produce the title compound.
📌 参考资料/链接：
参考文献标题:1,2,4-Trisubstd.benzenes as inhibitors of 15-lipoxygenase
文献作者:Sliskovic,D.R.; Picard,J.A.; Patt,W.C.; O'Brien,P.M.; Barvian,N.C.(Pfizer Inc.)
参考来源:WO 0196298
📄 详细内容
合成路线:Condensation of the indolyl aniline (I) with chlorosulfonyl isocyanate provided the sulfamoyl isocyanate (II).This was further converted to the title sulfamoyl carbamate by treatment with dodecyl alcohol (III) and triethylamine.
参考文献标题:Sulfamyl inhibitors of 15-lipoxygenase
文献作者:Barvian,N.C.; et al.
参考来源:222nd ACS Natl Meet (Aug 26 2001,Chicago) 2001,Abst MEDI 270