2,7-Dibromocryptolepine

Chemical Name: 2,7-Dibromo-5-methyl-10H-indolo[3,2-b]quinolin-5-ium iodide
项目整合开发状态: Preclinical
项目研究机构: London School Hygiene Tropical Medicine (Originator), University of Bradford (Originator)
合成路线:The condensation between 5-bromoisatin (I) and 3-acetoxy-1-acetyl-5-bromoindole (II) under basic conditions in an oxygen-free atmosphere produced the quindoline-11-carboxylic acid (III).This was decarboxylated to the dibromoquindoline (IV) upon heating in diphenyl ether.Finally,methylation of (IV) using iodomethane in tetramethylenesulfone furnished the title dibromocryptolepine.