新产品编号:2046035

Chemical Name: O15-[(6R,7R)-2-Carboxy-5-oxido-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-ylmethyl]retinoic acid; Retinoic acid (6R,7R)-4-carboxy-1-oxo-7-(2-phenoxyacetamido)cephem-3-ylmethyl ester
项目整合开发状态: Preclinical
项目研究机构: Academia Sinica (Originator), Shiraz University (Originator), University of Tehran (Originator)
合成路线:The silylation of 3'-iodocephalosporin (I) with Tms-Br in dichloromethane gives the trimethylsilyl ester (II),which is oxidized with MCPBA in the same solvent to yield the sulfoxide (III).Finally,this compound is condensed with the sodium salt of all-trans-beta-retinoic acid (IV) in DMF to afford the target conjugate.