新产品编号:2025469

Chemical Name: N2-(N-tert-Butoxycarbonyl)-N1-[(4aS,5R)-2-cyclohexyl-1,3-dioxoperhydropyrido[1,2-c]pyrimidin-5-yl]-L-tryptophanamide; N-[1(S)-[N-[(4aS,5R)-2-Cyclohexyl-1,3-dioxoperhydropyrido[1,2-c]pyrimidin-5-yl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamic acid tert-butyl
项目整合开发状态: Biological Testing
项目研究机构: CSIC (Originator), Universidad de Navarra (Originator)
合成路线:The trans-3-amino-2-piperidineacetic acid derivative (I),obtained as a 5:1 mixture of (2S,3R)- and (2R,3S)-isomers,was condensed with cyclohexyl isocyanate (II) to produce urea (III).Base-catalyzed cyclization of (III) gave rise to the dioxo pyridopyrimidine (IV).Acid cleavage of the Boc group of (IV) afforded the corresponding mixture of enantiomeric trans-amines (V).Acylation of amines (V) with N-Boc-L-tryptophan (VI) by means of BOP as the coupling reagent furnished the corresponding mixture of diastereomeric amides from which the target isomer was isolated by preparative TLC.