新产品编号:2022305

Chemical Name: N1,N1'-(2,5-Furandiyl)bis(3-methoxy-4,1-phenylene)]bis(pyridine-2-carboxamidine)
项目整合开发状态: Biological Testing
项目研究机构: Duke University (Originator), Georgia State University (Originator), University of Illinois at Chicago (Originator)
合成路线:Stille coupling between 2,5-bis(tri-n-butylstannyl)furan (I) and 2-bromo-5-nitroanisole (II) produced the 2,5-bis(4-nitrophenyl)furan (III),which was further reduced to the diamino derivative (IV) by catalytic hydrogenation over Pd/C.The title diamidine was then obtained by reaction of diamine (IV) with the S-(2-naphthylmethyl)thioimidate (V).

合成路线:Stille coupling between 2,5-bis(tri-n-butylstannyl)furan (I) and 2-bromo-5-nitrotoluene (II) produced the 2,5-bis(4-nitrophenyl)furan (III),which was further reduced to the diamino derivative (IV) by catalytic hydrogenation over Pd/C.The title diamidine was then obtained by reaction of diamine (IV) with the (S)-(2-naphthylmethyl)thioimidate (V).