新产品编号:2019141
Chemical Name: 1,5-Bis[4,7-bis(7-chloroquinolin-4-yl)-1,4,7-triazanonan-1-yl]pentan-1,5-dione
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator), Tibotec-Virco (Originator)
合成路线:Condensation of 1,4,7-triazacyclononane (I) with 4,7-dichloroquinoline (II) produced the disubstituted derivative (III).Then,coupling of glutaric acid (IV) with amine (III) using bromo-tris-pyrrolidinophosphonium hexafluorophosphate gave the corresponding diamide.
📌 参考资料/链接：
参考文献标题:Antiplasmodial activity and cytotoxicity of bis-,tris-,and tetraquinolines with linear or cyclic amino linkers
文献作者:Girault,S.; Grellier,P.; Berceibar,A.; Maes,L.; Lemi鑢e,P.; Mouray,E.; Davioud-Charvet,E.; Sergheraert,C.
参考来源:J Med Chem 2001,44(11),1658