TU-753

Chemical Name: 17-(2-Methyl-2-propenyl)-4,5alpha-epoxy-3,14-dihydroxy-6,7-didehydroindolo[2',3':6,7]morphinan; (4bS,8R,8aS,14bR)-7-(2-Methyl-2-propenyl)-6,7,8,9,14,14b-hexahydro-5H-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a-diol
项目整合开发状态: Biological Testing
项目研究机构: National Institute on Drug Abuse (Originator), National Institutes of Health (Originator), University of Arizona (Originator)
合成路线:Noroxymorphindole (III) was prepared by Fischer indole synthesis from noroxymorphone (I) and phenylhydrazine (II) under acidic conditions.Alkylation of (III) with 2-methyl-2-propenyl bromide (IV) in the presence of NaHCO3 in DMF afforded the title compound.