RHPS03, NSC-714186, RHPS3
Chemical Name: 3,6,8,11,13-Pentamethyl-8H-quino[4,3,2-kl]acridin-13-ium methylsulfate
项目整合开发状态: Biological Testing
项目研究机构: Institute of Cancer Research (Originator), University of Nottingham (Originator)
合成路线:The title compound was obtained in a one-pot procedure by dimerization of 1,2-dimethyl-6-fluoroquinolinium methosulfate (I) in ethanolic piperidine,giving intermediate (II),which spontaneously rearranged to the title quinoacridinium salt.
合成路线:The title compound was obtained in a one-pot procedure by dimerization of 1,2,6-trimethylquinolinium methosulfate (I) in ethanolic piperidine,giving intermediate (II),which spontaneously rearranged to the title quinoacridinium salt.
📌 参考资料/链接：
参考文献标题:Antitumor polycyclic acridines.8.Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts
文献作者:Heald,R.A.; Modi,C.; Cookson,J.C.; Hutchinson,I.; Laughton,C.A.; Gowan,S.M.; Kelland,L.R.; Stevens,M.F.G.
参考来源:J Med Chem 2002,45(3),590