CRL-8277
Chemical Name: N-[2-(5,10-Dioxo-5,10-dihydropyrido[3,2-g]quinolin-4-yl)phenyl]-2,2,2-trifluoroacetamide
项目整合开发状态: Preclinical
项目研究机构: Lafon (Originator)
合成路线:The cyclization of quinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III),which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.
合成路线:The cyclization of dimethylhydrazone (I) with 4-methoxyquinoline-5,8-dione (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III),which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.
合成路线:The cyclization of 4-methoxyquinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.
合成路线:The cyclization of dimethylhydrazone (I) with quinoline-5,8-dione (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.
📌 参考资料/链接：
参考文献标题:Pharmaceutical compsn.based on polyaromatic cpds.
文献作者:Kiss,R.; Bontemps-Subielos,N.; Frydman,A.; Darro,F.; Bastide,J.; Deflourne,E.(Laboratoires L.Lafon)
参考来源:FR 2790954; WO 0055160
📄 详细内容
合成路线:The cyclization of quinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III),which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.
合成路线:The cyclization of dimethylhydrazone (I) with 4-methoxyquinoline-5,8-dione (II) in refluxing acetic anhydride gives the pyridoquinolinedione (III),which is finally cyclized to the target pentacyclic ketone by means of TFA in refluxing dichloromethane.
合成路线:The cyclization of 4-methoxyquinoline-5,8-dione (I) with dimethylhydrazone (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.
合成路线:The cyclization of dimethylhydrazone (I) with quinoline-5,8-dione (II) in refluxing acetic anhydride gives the target pyridoquinolinedione.
参考文献标题:Synthesis and characterization of the antitumor activities of analogues of meridine,a marine pyridoacridine alkaloid
文献作者:Delfourne,E.; Darro,F.; Bontemps-Subielos,N.; Decaestecker,C.; Bastide,J.; Frydman,A.; Kiss,R.
参考来源:J Med Chem 2001,44(20),3275