新产品编号:1033555
Chemical Name: (2aR,4S,4aS,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-[3(S)-benzamido-2(R)-hydroxy-3-phenylpropionyloxy]-12-benzoyloxy-4,11-dihydroxy-4a,8,13,13-tetramethyl-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benz[1,2-b]oxet-5-one
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator)
合成路线:Conversion of paclitaxel (I) into 10-deacetoxypaclitaxel is achieved by electrolytic reduction or,alternatively,by deoxygenation,reduction and beta-elimination of the acetoxy group by means of SmI2 and HOAc.
📌 参考资料/链接：
参考文献标题:Process for the preparation of taxane derivs.,novel taxanes so obtained and antitumour and antileukaemia compsns.containing same
文献作者:Bourzat,J.-D.; Commer鏾n,A.; Deprez,D.; Pulicani,J.-P.(Aventis Pharma SA)
参考来源:JP 1996503261; WO 9411547
📄 详细内容
合成路线:Conversion of paclitaxel (I) into 10-deacetoxypaclitaxel is achieved by electrolytic reduction or,alternatively,by deoxygenation,reduction and beta-elimination of the acetoxy group by means of SmI2 and HOAc.
参考文献标题:A one-step synthesis of a deuterated paclitaxel analogue: 10-Deacetoxy-(10alpha-2H)paclitaxel
文献作者:Dutta,D.; Hadd,H.; Vander Velde,D.G.; Georg,G.I.
参考来源:Bioorg Med Chem Lett 1999,9(23),3277