新产品编号:2001739

Chemical Name: N2-[3-[[1(R)-(Benzyloxycarbonylamino)-2-phenylethyl](hydroxy)phosphoryl]-2-(2-naphthylsulfanylmethyl)propionyl]-L-tryptophanamide
项目整合开发状态: Biological Testing
项目研究机构: University of Athens (Originator)
合成路线:The title compound was prepared starting from the phosphinic dipeptide (I).Deprotection of the tert-butyl ester of (I) under acidic conditions afforded the carboxylic acid (II).This was then coupled with tryptophan amide (III) using EDC and HOBt to produce (IV).Finally,conjugate addition of 2-naphthalenethiol (V) to (IV) in the presence of NaOEt furnished the target thioether.