新产品编号:1998575
Chemical Name: 1-(5-Fluorobenzothien-2-yl)-3-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-ol
项目整合开发状态: Biological Testing
项目研究机构: Universidad de Navarra (Originator), Vita (Originator)
合成路线:Friedel-Crafts acylation of 5-fluorobenzothiophene (I) with 3-chloropropionyl chloride (II) in the presence of AlCl3 furnished the chloroketone (III).This was then condensed with N-(2-methoxyphenyl)piperazine (IV) to afford the piperazinyl ketone (V).Reduction of the keto group of (V) with NaBH4 then gave the title alcohol.
📌 参考资料/链接：
参考文献标题:New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants
文献作者:Mart韓ez,J.; Perez,S.; Oficialdegui,A.M.; Heras,B.; Orus,L.; Villanueva,H.; Palop,J.A.; Roca,J.; Mourelle,M.; Bosch,A.; Del Castillo,J.C.; Lasheras,B.; Tordera,R.; del Rio,J.; Monge,A.
参考来源:Eur J Med Chem 2001,36(1),55