新产品编号:1992247
Chemical Name: N-(2-Furylmethyl)-N'-(2-thiazolyl)thiourea
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Originator)
合成路线:Reaction of 2-aminothiazole (I) with thiocarbonyldiimidazole (II) in acetonitrile gave the intermediate thioimidazolide (III).This was then condensed with 2-furylmethylamine (IV) in hot DMF to yield the title thiourea derivative.
📌 参考资料/链接：
参考文献标题:Aromatic and heterocyclic thiazolyl thiourea cpds.and use
文献作者:Uckun,F.M.; Venkatachalam,T.K.(Parker Hughes Institute)
参考来源:WO 0232889
📄 详细内容
合成路线:Reaction of 2-aminothiazole (I) with thiocarbonyldiimidazole (II) in acetonitrile gave the intermediate thioimidazolide (III).This was then condensed with 2-furylmethylamine (IV) in hot DMF to yield the title thiourea derivative.
参考文献标题:Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds
文献作者:Venkatachalam,T.K.; Sudbeck,E.A.; Mao,C.; Uckun,F.M.
参考来源:Bioorg Med Chem Lett 2001,11(4),523