新产品编号:1987501
Chemical Name: 2-[4-[2-(4,5-Dihydroxy-10-oxo-9,10-dihydroanthracen-9-yl)-2-oxoethyl]phenyl]-N-methylacetohydroxamic acid
项目整合开发状态: Biological Testing
项目研究机构: Teva (Originator)
合成路线:Acylation of anthralin (I) either with phenylacetic acid (II) by means of EDC and pyridine in THF or with phenylacetyl chloride (III) by means of pyridine in THF affords compound (IV),which is finally converted into the desired hydroxamate by reaction with N-methyl-N-hydroxylamine and EDC in DMF.
合成路线:Acid chloride (II) was prepared by treatment of 4-phenylvaleric acid (I) with thionyl chloride.Condensation of acid chloride (II) with dithranol (III) in the presence of pyridine provided the title compound.
📌 参考资料/链接：
参考文献标题:10-Substd.18-dihydroxy-9(10H)anthracenone pharmaceuticals
文献作者:Reindl,H.; Muller,K.; Weigrebe,W.(Teva Pharmaceutical Industries Ltd.)
参考来源:US 5952390
📄 详细内容
合成路线:Acylation of anthralin (I) either with phenylacetic acid (II) by means of EDC and pyridine in THF or with phenylacetyl chloride (III) by means of pyridine in THF affords compound (IV),which is finally converted into the desired hydroxamate by reaction with N-methyl-N-hydroxylamine and EDC in DMF.
参考文献标题:Antipsoriatic anthrones with modulated redox properties.5.Potent inhibition of human keratinocyte growth.Induction of keratinocyte differentiation,and reduced membrane damage by novel 10-arylacetyl-1,8-dihydroxy-9(10H)-anthracenones
文献作者:M黮ler,K.; Reindl,H.; Breu,K.
参考来源:J Med Chem 2001,44(5),814