新产品编号:1971681

Chemical Name: 2-(4-Benzyl-3-oxo-3,4-dihydroquinoxalin-2-ylmethoxy)-N-phenylbenzamide
项目整合开发状态: Biological Testing
项目研究机构: University of Pennsylvania (Originator)
合成路线:3-Methylquinoxalin-2-one (III) was prepared by condensation of 1,2-phenylenediamine (I) with pyruvic acid (II).Alkylation of (III) with benzyl chloride furnished a mixture of the desired N-benzyl quinoxalinone (IV) and the O-benzyl isomer (V).These compounds were separated by means of radial chromatography.Bromination of (IV) with N-bromosuccinimide in the presence of benzoyl peroxide furnished the bromomethyl derivative (VI).Finally,condensation of bromide (VI) with salicylanilide (VII) under phase-transfer conditions provided the title compound.