D14
Chemical Name: 8-Chloro-5-oxidopyrazolo[5,1-c][1,2,4]benzotriazine-3-carboxylic acid thien-2-ylmethyl ester; 8-Chloro-3-(thien-2-ylmethoxycarbonyl)pyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide
项目整合开发状态: Preclinical
项目研究机构: Sanofi-Synth閘abo (Originator), Universit?degli Studi di Firenze (Originator), Universit?degli Studi di Pisa (Originator)
合成路线:The known 3-carboxy-8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide (I) is converted into the corresponding acid chloride (II) upon treatment with SOCl2.Subsequent condensation of acid chloride (II) with 2-thienylmethanol (III) in CHCl3 in the presence of pyridine leads to the title thienylmethyl ester.
📌 参考资料/链接：
参考文献标题:Benzodiazepine receptor ligands.7.Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide.3-(2-Thienylmethoxycarbonyl) derivative: An anxioselective agent in rodents
文献作者:Costanzo,A.; Guerrini,G.; Ciciani,G.; Bruni,F.; Costagli,C.; Selleri,S.; Besnard,F.; Costa,B.; Martini,C.; Malmberg Aiello,P.
参考来源:J Med Chem 2002,45(26),5710