DV-182

Chemical Name: 8-[2-[4-(2,5-Dichlorophenyl)piperazin-1-yl]-1-methylethyl]-8-azaspiro[4.5]decane-7,9-dione
项目整合开发状态: Biological Testing
项目研究机构: Recordati (Originator)
合成路线:Mitsunobu coupling of 3,3-tetramethyleneglutarimide (I) with 1-chloro-2-propanol (II) afforded the N-(2-chloro-1-methylethyl) glutarimide (III).This was then condensed with N-(2,5-dichlorophenyl)piperazine (IV) in the presence of Et3N at 180 C to furnish the title compound.