RU-84687
Chemical Name: N2-Acetyl-N1-[1-(biphenyl-4-ylmethyl)-2-oxoperhydroazepin-3(S)-yl]-3-formyl-4-O-phosphono-L-tyrosinamide
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator)
合成路线:Alkylation of 2-(Boc-amino)caprolactam (I) with 4-(bromomethyl)biphenyl (II) in the presence of KOH and tetrabutylammonium iodide produced the N-(biphenylylmethyl) lactam (III).After Boc group cleavage with trifluoroacetic acid,the resulting amino lactam (IV) was coupled with the tyrosine derivative (V) using BOP to furnish the corresponding amide.
📌 参考资料/链接：
参考文献标题:SAR and rational design of Src SH2 binders around a heterocyclic scaffold identification of RU84687,a subnanomolar and Src SH2 selective binder
文献作者:Mandine,E.; Baholet,I.; Deprez,P.; et al.
参考来源:16th Int Symp Med Chem (Sept 18 2000,Bologna) 2000,Abst PA-17