AP-5280

Chemical Name: cis-Diammine platinum complex polymer composed of an HMPA copolymer bound to an amidomalonate chelator through a Gly-Phe-Leu-Gly linker
项目整合开发状态: Phase I/II
项目研究机构: Access Pharmaceuticals (Originator)
合成路线:The known N-(2-hydroxypropyl)-methacrylamide copolymer (I) which has a p-nitrophenyl peptide side chain is coupled to ethyl aminomalonate (II) in the presence of Et3N in DMF to give the corresponding amide (III).Alkaline hydrolysis of the diethyl malonate ester groups of (III) affords the sodium carboxylate salt (IV).This is then complexed with the platinum species,generated in situ from cisplatin (V) and silver nitrate,to produce the title polymer-linked platinum complex.