新产品编号:1028809
Chemical Name: 2-(2-Aminoethyl)-5-[2-(dimethylamino9ethylamino]indazolo[4,3-gh]isoquinolin-6(2H)-one
项目整合开发状态: Biological Testing
项目研究机构: Roche (Originator), University of Vermont (Originator)
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-(dimethylamino)ethylhydrazine (II) gives 2-[2-(dimethylamino)ethyl]-5-(tosyloxy)indazolo[4,3-gh]isoquinolin-6(2H)-one (III),which is finally condensed with N,N-dimethylethylene-1,2-diamine (IV) to afford the title compound.
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-aminoethylhydrazine (II) gives 2-(2-aminoethyl)-5-(tosyloxy)indazolo[4,3-gh] isoquinolin-6(2H)-one (III),which is finally condensed with N,N-dimethylethylene-1,2-diamine (IV) to afford the title compound.
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-(dimethylamino)ethylhydrazine (II) gives 2-[2-(dimethylamino)ethyl]-5-(tosyloxy)indazolo[4,3-gh]isoquinolin-6(2H)-one (III),which is finally condensed with ethylene-1,2-diamine (IV) to afford the title compound.
📌 参考资料/链接：
参考文献标题:Synthesis and antitumor evalution of 2,5-disubstituted-indazolo[4,3-gh]isoquinoline-6(2H)-ones (9-aza-anthrapyrazoles)
文献作者:Menta,E.; et al.
参考来源:211th ACS Natl Meet (March 24-28,New Orleans) 1996,Abst MEDI 076
📄 详细内容
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-(dimethylamino)ethylhydrazine (II) gives 2-[2-(dimethylamino)ethyl]-5-(tosyloxy)indazolo[4,3-gh]isoquinolin-6(2H)-one (III),which is finally condensed with N,N-dimethylethylene-1,2-diamine (IV) to afford the title compound.
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-aminoethylhydrazine (II) gives 2-(2-aminoethyl)-5-(tosyloxy)indazolo[4,3-gh] isoquinolin-6(2H)-one (III),which is finally condensed with N,N-dimethylethylene-1,2-diamine (IV) to afford the title compound.
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-(dimethylamino)ethylhydrazine (II) gives 2-[2-(dimethylamino)ethyl]-5-(tosyloxy)indazolo[4,3-gh]isoquinolin-6(2H)-one (III),which is finally condensed with ethylene-1,2-diamine (IV) to afford the title compound.
参考文献标题:Antitumor aza-anthrapyrazoles
文献作者:Krapcho,A.P.; Menta,E.
参考来源:Drugs Fut 1997,22(6),641
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-(dimethylamino)ethylhydrazine (II) gives 2-[2-(dimethylamino)ethyl]-5-(tosyloxy)indazolo[4,3-gh]isoquinolin-6(2H)-one (III),which is finally condensed with N,N-dimethylethylene-1,2-diamine (IV) to afford the title compound.
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-aminoethylhydrazine (II) gives 2-(2-aminoethyl)-5-(tosyloxy)indazolo[4,3-gh] isoquinolin-6(2H)-one (III),which is finally condensed with N,N-dimethylethylene-1,2-diamine (IV) to afford the title compound.
合成路线:The cyclization of 9-fluoro-6-(tosyloxy)-5,10-dihydrobenzo[g]isoquinoline-5,10-dione (I) with 2-(dimethylamino)ethylhydrazine (II) gives 2-[2-(dimethylamino)ethyl]-5-(tosyloxy)indazolo[4,3-gh]isoquinolin-6(2H)-one (III),which is finally condensed with ethylene-1,2-diamine (IV) to afford the title compound.
参考文献标题:6,9-Disubstituted benz[g]isoquinoline-5,10-diones,key intermediates for the synthesis of antitumor 2,5-disubstituted-indazolo[4,3-gh]isoquinoline-6(2H)-ones (9-aza-anthrapyrazoles)
文献作者:Gallagher,C.E.; Maresch,M.J.; Krapcho,A.P.; et al.
参考来源:25th Natl Med Chem Symp (June 18,Univ.Michigan,Ann Arbor) 1996,Abst.15