新产品编号:1911565

Chemical Name: (1S,5R,6S)-6-[1(R)-Hydroxyethyl]-2-methoxy-1-methyl-1-carba-2-penem-3-carboxylic acid potassium salt
项目整合开发状态: Biological Testing
项目研究机构: Ludwig-Maximilians-Univ. M黱chen (Originator)
合成路线:Cyclization of azetidinone (I) by means of catalyst Rh2(OAc)4 in toluol provides carbapenam (II),which is treated with SiO2 in EtOAc to produce epimerization to the alpha-methyl compound (III).Methylation of (III) with diazomethane in dioxane affords carbapenem (IV),which is hydrogenolyzed over Pd/C in EtOAc and finally saponified with KHCO3 in H2O to furnish the desired compound.