NO-Paracetamol, NCX-701

Chemical Name: 4-(Nitrooxy)butyric acid 4-acetamidophenyl ester
项目整合开发状态: Phase II
项目研究机构: NicOx (Originator)
合成路线:The esterification of paracetamol (I) with 4-bromobutyric acid (II) by means of DCC and DMAP in DMF gives the corresponding ester (III),which is finally treated with AgNO3 in hot acetonitrile to yield the target nitrate ester.