L-838417

Chemical Name: 7-tert-Butyl-3-(2,5-difluorophenyl)-6-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)[1,2,4]triazolo[4,3-b]pyridazine
项目整合开发状态: Preclinical
项目研究机构: Merck Sharp & Dohme (Originator)
合成路线:Decarboxylative radical alkylation of 3,6-dichloropyridazine (I) using pivalic acid (II) and ammonium persulfate in the presence of silver nitrate catalyst furnished 3,6-dichloro-4-tert-butylpyridiazine (III).This was then condensed with 2,5-difluorobenzoyl hydrazide (IV) to produce the triazolopyridazine derivative (V).The remaining chlorine atom was finally displaced with (2-methyl-2H-1,2,4-triazol-3-yl)methanol (VI) using NaH in DMF to afford the title compound.