新产品编号:1848285
Chemical Name: 2-(6-Methoxy-2-naphthyl)propionic acid 2-[2-(4-methyl-1-piperazinyl)acetoxy]ethyl ester
项目整合开发状态: Preclinical
项目研究机构: University of Kuopio (Originator)
合成路线:The hydroxyethyl ester of naproxen (II) was synthesized by treatment of the sodium salt of naproxen (I) with 2-bromoethanol.Condensation of (II) with (4-methyl-1-piperazinyl)acetic acid (III) in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine yielded the title compound.
📌 参考资料/链接：
参考文献标题:Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (naproxen) for topical drug delivery
文献作者:Rautio,J.; Nevalainen,T.; Taipale,H.; Vepsalainen,J.; Gynther,J.; Laine,K.; Jarvinen,T.
参考来源:J Med Chem 2000,43(8),1489