NO-prednisolone, NCX-1015

Chemical Name: 11beta,17alpha-Dihydroxy-21-[4-(nitrooxymethyl)benzoyloxy]pregna-1,4-diene-3,20-dione
项目整合开发状态: Phase I
项目研究机构: NicOx (Originator), William Harvey Research Institute (Originator)
合成路线:The esterification of prednisolone (I) with 4-(chloromethyl)benzoyl chloride (II) by means of TEA in THF gives the corresponding benzoate (II),which is treated with silver nitrate in refluxing acetonitrile/THF to yield the target nitrate ester.