新产品编号:1841957
Chemical Name: N-(2,6-Diisopropylphenyl)-N'-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]urea
项目整合开发状态: Preclinical
项目研究机构: Elan (Originator), Pfizer (Originator)
合成路线:The title urea derivative was obtained by condensation of 2,6-diisopropylphenyl isocyanate (I) with alpha-methyl-3-(trifluoromethyl)phenylethyl amine (II) in the presence of Et3N,followed by treatment with potassium sarcosinate as isocyanate scavenger.
📌 参考资料/链接：
参考文献标题:Synthesis and biological evaluation of substituted alpha-methyl-3-(trifluoromethyl)benzeneethanamine derivatives as novel N-type calcium channel blockers
文献作者:Warmus,J.; Weber,M.l.; Stoehr,S.; Downing,D.; Kornberg,B.E.; Rock,D.M.; Rafferty,M.F.; Szoke,B.G.; Nikam,S.S.
参考来源:219th ACS Natl Meet (March 26 2000,San Francisco) 2000,Abst MEDI 260