新产品编号:1845121

Chemical Name: 2(S)-(3,5-Dimethylisoxazol-4-ylsulfonamido)-3-[3-(4-pyridinyl)-3-azaspiro[5.5]undec-9-ylcarboxamido]propionic acid
项目整合开发状态: Preclinical
项目研究机构: Millennium (Originator), Lilly (Codevelopment)
合成路线:The N-Boc protected azaspirocarboxylic acid (I) was simultaneously deprotected and esterified with ethanolic HCl to produce ester (II).Palladium-catalyzed coupling of azaspirocycle (II) with 4-bromopyridine (III) afforded the pyridyl-azaspirocarboxylic acid (IV).This was then condensed with the known amino ester (V) using EDC and HOBt to yield amide (VI).Finally,acid hydrolysis of the ethyl ester group of (VI) furnished the title compound.