Bemesetron, MDL-72222
3-托烷-3,5-二氯苯甲酸Chemical Name: 1alphaH,3alpha,5alphaH-Tropan-3-yl-3,5-dichlorobenzoate; 3,5-Dichlorobenzoic acid endo-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
CAS No. 40796-97-2
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator)
合成路线:By reaction of tropine (I) with 3,5-dichlorobenzoyl chloride (II) at 140 C.
📌 参考资料/链接：
参考文献标题:Treatment og migraine with substituted tropyl benzoate derivatives
文献作者:Fozard,J.R.; Gittos,M.W.(Aventis Pharma SA)
参考来源:EP 0067770; JP 58000978
📄 详细内容
合成路线:By reaction of tropine (I) with 3,5-dichlorobenzoyl chloride (II) at 140 C.
参考文献标题:MDL-72222
文献作者:Pento,J.T.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1985,10(10),820
合成路线:The synthesis of [11C]-labeled MDL-72222 for use in PET studies of the 5-HT3 receptor by methylation of 3,5-dichlorobenzoic acid 8-azabicyclo[3.2.1]oct-3-yl ester (I) with [11C]-labeled methyl iodide in hot acetonitrile has been described.
参考文献标题:Synthesis and regional rat brain distribution of [C-11]MDL 72222 - A 5HT3 receptor antagonist
文献作者:Lasne,M.C.; Debruyne,D.; Moulin,M.; Baron,J.C.; Camsonne,R.; Barre,L.; Bonvento,G.; Gourand,F.
参考来源:Appl Radiat Isot - Int J Radiat Appl Instrum Part A 1992,43(4),509
产品链接: CAS No. 40796-97-2››