Flubichin methanesulfonate, VUFB-12950
3-{2-[(2',4'-二氟be苯基-4-基)氧]乙基}喽那唑仑-4(3H)-酮Chemical Name: 3-[2-(2',4'-Difluorobiphenyl-4-yloxy)ethyl]quinazoline-4(3H)-one methanesulfonate
CAS No. 131587-93-4 (free base), 131587-94-5 (HCl)
项目整合开发状态: Preclinical
项目研究机构: Res. Inst. Pharmacy Biochemistry (VUFB) (Originator)
合成路线:Flubichin (V) is prepared by a reaction of 4(3H)-quinazolinone (IV) with 2',4'-difluoro-4-(2-chloroethoxy)biphenyl (III).Compound (III) can be prepared by reaction of 2',4'-difluoro-4-hydroxybiphenyl (I) with 2-chloroethyl p-toluene sulfonate (II).Methanesulfonate of flubichin is obtained by reaction of flubichin base (V) with methanesulfonic acid in chloroform.
📌 参考资料/链接：
参考文献标题:Ether deriv.of 4-[3H]-quinazoline,a process for the preparation thereof,and pharmaceutical compsns
文献作者:Fisnerov? L.; Brunov? B.; Maturov? E.; Grimov? J.(SPOFA - United Pharmaceutical Works)
参考来源:AU 8942880; EP 0367944; JP 1990172977
📄 详细内容
合成路线:Flubichin (V) is prepared by a reaction of 4(3H)-quinazolinone (IV) with 2',4'-difluoro-4-(2-chloroethoxy)biphenyl (III).Compound (III) can be prepared by reaction of 2',4'-difluoro-4-hydroxybiphenyl (I) with 2-chloroethyl p-toluene sulfonate (II).Methanesulfonate of flubichin is obtained by reaction of flubichin base (V) with methanesulfonic acid in chloroform.
参考文献标题:Flubichin Methanesulfonate
文献作者:Rejholec,V.
参考来源:Drugs Fut 1991,16(8),715
产品链接: CAS No. 131587-93-4››