Pelanserin hydrochloride, TR-2515
3-[3-(4-苯基-1-吡嗪基)丙基]奎那佐林-2,4(1H,3H)-二酮dro氯化物培兰色林Chemical Name: 3-[3-(4-Phenyl-1-piperazinyl)propyl]quinazoline-2,4(1H,3H)-dione hydrochloride
CAS No. 42877-18-9, 4052-11-3 (diHCl), 2208-51-7 (free base)
项目整合开发状态: Phase II
项目研究机构: Bayer (Originator)
合成路线:The reaction of isatoic anhydride (I) with 1-(3-aminopropyl)-4-phenylpiperazine (II) in DMF at 40-60 C gives the o-aminobenzamide derivative (III),which is then cyclized by the action of phosgene in refluxing chlorobenzene.
📌 参考资料/链接：
参考文献标题:TR-2515
文献作者:Schut,R.N.; Hong,E.
参考来源:Drugs Fut 1985,10(11),929
📄 详细内容
合成路线:The reaction of isatoic anhydride (I) with 1-(3-aminopropyl)-4-phenylpiperazine (II) in DMF at 40-60 C gives the o-aminobenzamide derivative (III),which is then cyclized by the action of phosgene in refluxing chlorobenzene.
参考文献标题:New sedative and hypotensive 3-substituted 2,4(1H,3H)-quinazolinediones
文献作者:Hayao,S.; Havera,H.J.; Strycker,W.G.; Leipzig,T.J.; Kulp,R.A.; Hartzler,H.E.
参考来源:J Med Chem 1965,8(6),807
产品链接: CAS No. 42877-18-9›› 产品链接: CAS No.2208-51-7››