P-0285
3,5-吡啶二羧酸,1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-,3-[2-[4-(3,4-二氯苯)-1-哌帕拉嗪基]乙基] 5-甲基酯Chemical Name: Methyl 2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyri-dine-3,5-dicarboxylate
CAS No. 91040-25-4
项目整合开发状态: Phase II
项目研究机构: Pierrel (Originator)
合成路线:Hantzsch condensation of 2-[4-(3,4-dichlorophenyl)piperazin-1-yl]ethyl acetylacetate (III) with methyl 3-aminocrotonate (II) and 3-nitrobenzaldehyde (I) in eftuxing isopropanol affords title compound.
📌 参考资料/链接：
参考文献标题:Dihydropyridines with an antagonistic activity to
文献作者:Zumin Tricerri,S.; Casagrande,C.; De Marchi,F.; Nicola,M.(Pierrel SpA)
参考来源:EP 0097821; US 4894460
📄 详细内容
合成路线:Hantzsch condensation of 2-[4-(3,4-dichlorophenyl)piperazin-1-yl]ethyl acetylacetate (III) with methyl 3-aminocrotonate (II) and 3-nitrobenzaldehyde (I) in eftuxing isopropanol affords title compound.
参考文献标题:P-0285
文献作者:Bani,M.; Favara,D.
参考来源:Drugs Fut 1988,13(4),321
产品链接: CAS No. 91040-25-4››