KF-19418

3,5-二苯基-4,5-二氢-1H-吡唑并[4,3-c][1,8]二氮杂萘-4-酮Chemical Name: 3,5-Diphenyl-4,5-dihydro-1H-pyrazolo[4,3-c][1,8]naphthyridin-4-one
CAS No. 147508-06-3
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator)
合成路线:Friedel-Crafts acylation of 4-hydroxy-1-phenyl[1,8]naphthyridin-2(1H)-one (I) with benzoyl chloride (II) using AlCl3 in hot nitrobenzene produced the 3-benzoyl naphthyridinone (III).This was cyclized to the title pyrazolonaphthyridinone by treatment with hydrazine in refluxing HOAc.