ME-93
3,5-二氯-N-甲基苄胺盐酸盐 1-(3,5-二氯苯基)-N-甲基甲胺 Chemical Name: 3,5-Dichloro-N-methylbenzylamine monohydrochloride
CAS No. 90389-22-3, 90390-21-9 (free base)
项目整合开发状态: Preclinical
项目研究机构: Universit鋞 Regensburg (Originator)
合成路线:3,5-Dichlorobenzoic acid (I) is reduced with LiAlH4 to give 3,5-dichlorobenzyl alcohol (II).The latter is selectively oxidized with MnO2,yielding 3,5-dichlorobenzaldehyde (III).The condensation of (III) with methylamine gives the corresponding imine (IV),which can be reduced to the benzylamine (V) either with LiAlH4 or NaBH4.The hydrochloride is precipitated with etheric HCl.
📌 参考资料/链接：
参考文献标题:ME-93
文献作者:Meindl,W.; Sch鰊enberger,H.; Seydel,J.K.; Dhople,A.M.
参考来源:Drugs Fut 1987,12(12),1108
📄 详细内容
合成路线:3,5-Dichlorobenzoic acid (I) is reduced with LiAlH4 to give 3,5-dichlorobenzyl alcohol (II).The latter is selectively oxidized with MnO2,yielding 3,5-dichlorobenzaldehyde (III).The condensation of (III) with methylamine gives the corresponding imine (IV),which can be reduced to the benzylamine (V) either with LiAlH4 or NaBH4.The hydrochloride is precipitated with etheric HCl.
参考文献标题:Benzylamines: Synthesis and evaluation of antimycobacterial properties
文献作者:Meindl,W.R.; von Angerer,E.; Schonenberge,H.; Ruckdeschel,G.
参考来源:J Med Chem 1984,27(9),1111
产品链接: CAS No. 90389-22-3›› 产品链接: CAS No.90390-21-9››