Didox, NSC-324360
3,4-二羟基苯甲羟肟酸Chemical Name: 3,4-Dihydroxybenzohydroxamic acid; N,3,4-Trihydroxybenzamide
CAS No. 69839-83-4
项目整合开发状态: Phase II
项目研究机构: Molecules for Health (Originator)
合成路线:The esterification of 3,4-dihydroxybenzoic acid (I) with refluxing methanol - H2SO4 gives the corresponding methyl ester (II),which is then treated with hydroxylamine in water containing NaOH.
📌 参考资料/链接：
参考文献标题:Hydroxy benzohydroxamic acids and benzamides
文献作者:Van't Riet,B.; Elford,H.L.; Wampler,G.L.(Molecules for Health,Inc.)
参考来源:US 4263322
📄 详细内容
合成路线:The esterification of 3,4-dihydroxybenzoic acid (I) with refluxing methanol - H2SO4 gives the corresponding methyl ester (II),which is then treated with hydroxylamine in water containing NaOH.
参考文献标题:Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: Inhibition of ribonucleotide reductase and antitumor activity
文献作者:Van't Riet,B.; Wampler,G.L.; Elford,H.W.
参考来源:J Med Chem 1979,22(5),589-92
合成路线:The esterification of 3,4-dihydroxybenzoic acid (I) with refluxing methanol - H2SO4 gives the corresponding methyl ester (II),which is then treated with hydroxylamine in water containing NaOH.
参考文献标题:DIDOX
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1990,15(1),22
产品链接: CAS No. 69839-83-4››