合成路线:Hydrazine hydrate (I) is added dropwise under stirring to ethyl acetoacetate (II),which has been heated to 140 C,water and ethanol formed in the reaction are distilled off,and the mixture is heated at reflux.Upon completion of the reaction,the mixture is allowed to stand at room temperature,and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.
合成路线:Suspension of 3-methyl-2-pyrazolin-5-one (I) is added dropwise under stirring to ethyl acetoacetate (II),which has been heated to 140 C,water and ethanol formed in the reaction are distilled off,and the mixture is heated at reflux.Upon completion of the reaction,the mixture is allowed to stand at room temperature,and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.
参考文献标题:Studies on heterocyclic compounds.6.Synthesis and analgesic and antiinflammatory activities of 3,4-dimethylpyrano[2,3-c]pyrazol-6-one derivatives
文献作者:Kuo,S.C.; Huang,L.J.; Nakamura,H.
参考来源:J Med Chem 1984,27(4),539
合成路线:Hydrazine hydrate (I) is added dropwise under stirring to ethyl acetoacetate (II),which has been heated to 140 C,water and ethanol formed in the reaction are distilled off,and the mixture is heated at reflux.Upon completion of the reaction,the mixture is allowed to stand at room temperature,and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.
合成路线:Suspension of 3-methyl-2-pyrazolin-5-one (I) is added dropwise under stirring to ethyl acetoacetate (II),which has been heated to 140 C,water and ethanol formed in the reaction are distilled off,and the mixture is heated at reflux.Upon completion of the reaction,the mixture is allowed to stand at room temperature,and the solid thus separated is collected and recrystallized from ethanol to obtain the title compound.
参考文献标题:
文献作者:
参考来源:J Taiwan Pharm Assoc 1979,3147-55
产品链接: CAS No. 5203-98-5››