Estrone 3-oleate, Oleoyl-estrone
3-(4-苄氧基苯基)-DL-β-丙氨酸醇Chemical Name: 3-Oleoylestra-1,3,5(10)trien-17-one; 3-[1-Oxo-9(Z)-octadecenyloxy]estra-1,3,5(10)-trien-17-one
CAS No. 180003-17-2
项目整合开发状态: Preclinical
项目研究机构: Oleoyl-Estrone Developments (Proprietary), Salvat (Originator), Manhattan Pharmaceuticals (Licensee)
合成路线:Oleoyl-estrone can be obtained by direct condensation of commercially available estrone (I) and oleoyl chloride (II) in anhydrous pyridine at 40 C.
📌 参考资料/链接：
参考文献标题:Fatty-acid monoesters of estrogens for the treatment of obesity and/or overweight
文献作者:Alemany,M.(Laboratorios Salvat SA)
参考来源:EP 0771817; US 5798348
📄 详细内容
合成路线:Oleoyl-estrone can be obtained by direct condensation of commercially available estrone (I) and oleoyl chloride (II) in anhydrous pyridine at 40 C.
参考文献标题:Rats receiving the slimming agent oleoyl-estrone in liposomes (Merlin-2) decrease food intake but maintain thermogenesis
文献作者:Sanchis,D.; Balada,F.; Pic? C.; Grasa,M.M.; Virgili,J.; Farrerons,C.; Palou,A.; Fern醤dez-L髉ez,J.A.; Remesar,X.; Alemany,M.
参考来源:Arch Physiol Biochem 1997,105(7),663
合成路线:Oleoyl-estrone can be obtained by direct condensation of commercially available estrone (I) and oleoyl chloride (II) in anhydrous pyridine at 40 C.
参考文献标题:Oleoyl-Estrone
文献作者:del Fresno,M.; Cullell-Young,M.
参考来源:Drugs Fut 2002,27(7),648
产品链接: CAS No. 180003-17-2››