ST-1959, DL-111-IT
3-(2-乙基苯基)-5-(3-甲氧基苯基)-1H-1,2,4-三唑Chemical Name: 3-(2-Ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole; 5-(2-Ethylphenyl)-3-(3-methoxyphenyl)-1H-1,2,4-triazole
CAS No. 69095-83-6
项目整合开发状态: Phase I
项目研究机构: Lepetit (Originator), Sigma-Tau (Originator)
合成路线:By cyclization of ethyl m-methoxybenzimidate (I) with 2-ethylbenzoyl hydrazide (II) at 125 C.
📌 参考资料/链接：
参考文献标题:3,5-Disubstd.-1H-1,2,4-triazoles
文献作者:Omodei Sale,A.; Consonni,P.; Galliani,G.; Lerner,L.(Lepetit SpA)
参考来源:DE 2819372
📄 详细内容
合成路线:By cyclization of ethyl m-methoxybenzimidate (I) with 2-ethylbenzoyl hydrazide (II) at 125 C.
参考文献标题:DL-111-IT
文献作者:Hillier,K.; Blancafort,P.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(12),875
合成路线:The condensation of ethyl 3-metboxybenzimidate (I) with 2-ethybenzoic hydrazide (II) in refluxing CH2Cl2 gives the benzoylamidrazone (III),which is then cyclized by means of K2CO3 in refluxing 2-etoxyethanol.
参考文献标题:A new class of nonhormonal pregnancy-terminating agents.Synthesis and contragestational activity of 3,5-diaryl-s-triazoles
文献作者:Omodei-Sal? A.; Consonni,P.; Galliani,G.
参考来源:J Med Chem 1983,26(8),1187-92
合成路线:A new method for the synthesis of DL-111-IT has been reported:By cyclization of m-methoxybenzonitrile (I) with ethoxybenzoylhydrazide (II) in refluxing methanol.
参考文献标题:Reaction of substituted acid hydrazides with substituted benzonitriles: Formatio of isomeric triazoles
文献作者:Neelima; Bhaduri,A.P.
参考来源:Indian J Chem 1983,22B(1),79-80
产品链接: CAS No. 69095-83-6››