合成路线:The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III),which is cyclized to ethyl 4-hydroxyquinoline-3-carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl.The reaction of (IV) with hot POCl3 affords ethyl 4-chloro-quinoline-3-carboxylate (V),which is finally cyclized with phenylhydrazine (VI) by heating at 105 C in xylene.(VI) is prepared in the usual way starting from aniline (I) by diazotation with NaNO2-HCl to phenyldiazonium chloride (VII),and reduction with SnCl2-HCl.
合成路线:The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III),which is cyclized to ethyl 4-hydroxyquinoline-3carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl.The reaction of (IV) with hot POCl3 affords ethyl-4-chloroquinoline-3-carboxylate (V),which is finally cyclized with 4-chlorophenylhydrazine (VIII) by heating at 105 C in xylene.(VIII) is prepared in the usual way starting from 4-chloroaniline (IX) by diazotation with NaNO2-HCl to 4-chlorophenyldiazonium chloride (X),and reduction with SnCl2-HCl.
参考文献标题:2-Arylpyrazolo[4,3-c]quinolin-3-ones: A partial novel agonist and antagonist of benzodiazepines
文献作者:Yokoyama,N.; Ritter,B.; Neubert,A.D.
参考来源:J Med Chem 1982,25(4),337-339
合成路线:The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III),which is cyclized to ethyl 4-hydroxyquinoline-3-carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl.The reaction of (IV) with hot POCl3 affords ethyl 4-chloro-quinoline-3-carboxylate (V),which is finally cyclized with phenylhydrazine (VI) by heating at 105 C in xylene.(VI) is prepared in the usual way starting from aniline (I) by diazotation with NaNO2-HCl to phenyldiazonium chloride (VII),and reduction with SnCl2-HCl.
合成路线:The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III),which is cyclized to ethyl 4-hydroxyquinoline-3carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl.The reaction of (IV) with hot POCl3 affords ethyl-4-chloroquinoline-3-carboxylate (V),which is finally cyclized with 4-chlorophenylhydrazine (VIII) by heating at 105 C in xylene.(VIII) is prepared in the usual way starting from 4-chloroaniline (IX) by diazotation with NaNO2-HCl to 4-chlorophenyldiazonium chloride (X),and reduction with SnCl2-HCl.
参考文献标题:
文献作者:Yokoyama,N.
参考来源:US 4312870
合成路线:The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III),which is cyclized to ethyl 4-hydroxyquinoline-3-carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl.The reaction of (IV) with hot POCl3 affords ethyl 4-chloro-quinoline-3-carboxylate (V),which is finally cyclized with phenylhydrazine (VI) by heating at 105 C in xylene.(VI) is prepared in the usual way starting from aniline (I) by diazotation with NaNO2-HCl to phenyldiazonium chloride (VII),and reduction with SnCl2-HCl.
合成路线:The condensation of aniline (I) with diethyl ethoxymethylenemalonate (II) by heating at 90 C gives diethyl anilinomethylenemalonate (III),which is cyclized to ethyl 4-hydroxyquinoline-3carboxylate (IV) by heating at 240 C in diphenyl ether-biphenyl.The reaction of (IV) with hot POCl3 affords ethyl-4-chloroquinoline-3-carboxylate (V),which is finally cyclized with 4-chlorophenylhydrazine (VIII) by heating at 105 C in xylene.(VIII) is prepared in the usual way starting from 4-chloroaniline (IX) by diazotation with NaNO2-HCl to 4-chlorophenyldiazonium chloride (X),and reduction with SnCl2-HCl.
参考文献标题:
文献作者:Yokoyama,N.
参考来源:EP 0022078
产品链接: CAS No. 77779-60-3››