Sch-28080
2-甲基-8-(苯基甲氧基)咪唑并[1,2-a]吡啶-3-乙腈Chemical Name: 2-Methyl-8-benzyloxyimidazo[1,2-a]pyridine-3-acetonitrile; 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
CAS No. 76081-98-6
项目整合开发状态: Preclinical
项目研究机构: Schering-Plough (Originator)
合成路线:By cyclization of 2-amino-3-benzyloxypyridine (I) with 3-chloro-4-oxopentanonitrile (II) by means of thiethylamine in ethanol.Compound (I) is prepared by benzylation of 2-amino-3-hydroxypyridine (III) with benzyl chloride (IV) by means of NaOH in water-CH2Cl2.Compound (II) is prepared by chlorination of 4-oxopentanonitrile (V) with SO2Cl2 in ether.
📌 参考资料/链接：
参考文献标题:SCH-28,080
文献作者:Hillier,K.; Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1982,7(10),755
📄 详细内容
合成路线:By cyclization of 2-amino-3-benzyloxypyridine (I) with 3-chloro-4-oxopentanonitrile (II) by means of thiethylamine in ethanol.Compound (I) is prepared by benzylation of 2-amino-3-hydroxypyridine (III) with benzyl chloride (IV) by means of NaOH in water-CH2Cl2.Compound (II) is prepared by chlorination of 4-oxopentanonitrile (V) with SO2Cl2 in ether.
参考文献标题:
文献作者:Puchalski,C.; Bristol,J.A.
参考来源:EP 0033094
产品链接: CAS No. 76081-98-6››