IMPY
6-碘-2-(4-二甲基氨基苯基)咪唑并[1,2-a]吡啶 Chemical Name: N-[4-[6-([125I]-Iodo)imidazo[1,2-a]pyridin-2-yl]phenyl]-N,N-dimethylamine
CAS No. 474012-78-7, 474012-75-4 (unlabeled)
项目整合开发状态: Preclinical
项目研究机构: University of Pennsylvania (Originator), University of Toronto (Originator), Washington University (Originator)
合成路线:Condensation between 2-bromo-4'-(dimethylamino)acetophenone (I) and 2-amino-5-bromopyridine (II) gives rise to the imidazopyridine (III).Subsequent palladium-catalyzed stannylation of (III) affords the tributyltin derivative (IV).The target radio-iodinated compound is then obtained by iododstannylation of (IV) with [125I] iodide in the presence of H2O2 (1,2)
📌 参考资料/链接：
参考文献标题:Amyloid plaque aggregation inhibitors and diagnostic imaging agents
文献作者:Kung,H.; Kung,M.-P.; Zhuang,Z.-P.(University of Pennsylvania)
参考来源:CA 2444214; EP 1381604; US 2003059369; WO 0285903
📄 详细内容
合成路线:Condensation between 2-bromo-4'-(dimethylamino)acetophenone (I) and 2-amino-5-bromopyridine (II) gives rise to the imidazopyridine (III).Subsequent palladium-catalyzed stannylation of (III) affords the tributyltin derivative (IV).The target radio-iodinated compound is then obtained by iododstannylation of (IV) with [125I] iodide in the presence of H2O2 (1,2)
参考文献标题:Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain
文献作者:Zhuang,Z.-P.; Kung,M.-P.; Wilson,A.; Lee,C.-W.; Plsl,K.; Hou,C.; Holtzman,D.M.; Kung,H.F.
参考来源:J Med Chem 2003,46(2),237
产品链接: CAS No.474012-75-4››