新产品编号:16329
2-氨基-4a,7-二甲基-4H-吩恶嗪-3-酮Chemical Name: 2-Amino-4a,7-dimethyl-4,4a-dihydro-3H-phenoxazin-3-one
CAS No. 114791-08-1
项目整合开发状态: Preclinical
项目研究机构: Tokyo Medical and Dental University (Originator)
合成路线:The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2,through the intermediate quinonimine (II).The reaction was performed with bovine hemolysates and also with purified human hemoglobin.
📌 参考资料/链接：
参考文献标题:An improved method for the rapid preparation of 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-on,a novel antitumor agent
文献作者:Tomoda,A.; Arai,S.; Ishida,R.; Shimamoto,T.; Ohnyashiki,K.
参考来源:Bioorg Med Chem Lett 2001,11(8),1057
📄 详细内容
合成路线:The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2,through the intermediate quinonimine (II).The reaction was performed with bovine hemolysates and also with purified human hemoglobin.
参考文献标题:Phenoxazinone synthesis by human hemoglobin
文献作者:Tomoda,A.; Hamashima,H.; Arisawa,M.; Kikuchi,T.; Tezuka,Y.; Koshimura,S.
参考来源:Biochim Biophys Acta 1992,117(3),306
合成路线:The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2,through the intermediate quinonimine (II).The reaction was performed with bovine hemolysates and also with purified human hemoglobin.
参考文献标题:Antitumor activity of 2-amino-4,4 alpha-dihydro-4 alpha,7-dimethyl-3H-phenoxazine-3-one,a novel phenoxazine derivative produced by the reaction of 2-amino-5-methylphenol with bovine hemolysate
文献作者:Ishida,R.; Yamanaka,S.; Kawai,H.; Ito,H.; Iwai,M.; Nishizawa,M.; Hamatake,M.; Tomoda,A.
参考来源:Anti-Cancer Drugs 1996,7(5),591
合成路线:The target phenoxazinone is obtained by reaction of 2-amino-5-methylphenol (I) with Hemoglobin-O2,through the intermediate quinonimine (II).The reaction was performed with bovine hemolysates and also with purified human hemoglobin.
参考文献标题:Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo
文献作者:Shimamoto,T.; Tomoda,A.; Ishida,R.; Ohyashiki,K.
参考来源:Clin Cancer Res 2001,7(3),704
产品链接: CAS No. 114791-08-1››