BE-6143, BDF-6143
2H-异哌多-2-胺,4-氯钼-(4,5-二氢-1H-吡达唑-2-基)-1,3-二氢,盐酸盐(1:1)Chemical Name: 4-Chloro-2-(2-imidazolin-2-ylamino)isoindoline hydrochloride
CAS No. 76727-72-5
项目整合开发状态: Preclinical
项目研究机构: GlaxoSmithKline (Originator)
合成路线:By condensation of 4-chloro-2-aminoisoindoline (I) with 1-acetylimidazolidin-2-one (II) by means of POCl3 at 100 C,followed by hydrolysis of the acetyl group with hot ethanol.
📌 参考资料/链接：
参考文献标题:Hypotensive 2-heterocycloaminoimidazolines
文献作者:Cohnen,E.(Beiersdorf-Lilly GmbH)
参考来源:DE 2816627; DE 2905501; FR 2423491; GB 2021100; JP 79151990; US 4221798
📄 详细内容
合成路线:By condensation of 4-chloro-2-aminoisoindoline (I) with 1-acetylimidazolidin-2-one (II) by means of POCl3 at 100 C,followed by hydrolysis of the acetyl group with hot ethanol.
参考文献标题:BDF-6143
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(2),100
产品链接: CAS No. 76727-72-5››