AA-2379
2H-吡拉唑[3,4-d]嘧啶-2-羧酸,7-丁基-4,5,6,7-四氢-3-(甲基氨基)-4,6-二氧基-5-丙基-,甲基酯Chemical Name: 7-Butyl-3-(methylamino)-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylic acid methyl ester
CAS No. 103446-98-6
项目整合开发状态: Phase II
项目研究机构: Takeda (Originator)
合成路线:The cyclization of 1-butyl-6-chloro-5-cyano-3-propyluracil (I) with methoxycarbonylhydrazine (II) in refluxing methanol yields 3-amino-7-butyl-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylic acid ethyl ester (III),which is then methylated with methyl iodide and K2CO3 in DMF.
📌 参考资料/链接：
参考文献标题:3-Aminopyrazolo(3,4-d)pyrimidine derivs.and production thereof
文献作者:Furukawa,Y.; Maki,Y.(Takeda Chemical Industries,Ltd.)
参考来源:EP 0166054
📄 详细内容
合成路线:The cyclization of 1-butyl-6-chloro-5-cyano-3-propyluracil (I) with methoxycarbonylhydrazine (II) in refluxing methanol yields 3-amino-7-butyl-4,6-dioxo-5-propyl-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidine-2-carboxylic acid ethyl ester (III),which is then methylated with methyl iodide and K2CO3 in DMF.
参考文献标题:AA-2379
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1990,15(5),443
产品链接: CAS No. 103446-98-6››