网站主页>>>项目整合精选>>>项目整合精选>>>Perfosfamide, NPC-15520, 4-HPCy, 40,487, NSC-181815, 4-HC

Perfosfamide, NPC-15520, 4-HPCy, 40,487, NSC-181815, 4-HC

2H-1,3,2-氧氮磷-2-胺,N,N-双(2-氯乙基)四氢-4-氢过氧-,2-氧化物,(2R,4R)-rel- 培磷酰胺 Chemical Name: (?-cis-2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide; (?-cis-2-[Bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; 4-Hydroperoxycyclophosphamide
CAS No. 62435-42-1, 39800-16-3 (undefined stereoch.)
项目整合开发状态: Phase III
项目研究机构: Scios (Originator)
合成路线:This compound can be obtained in three different ways:1) By ozonolysis of 3-butenyl-N,N-bis(2-chloroethyl)phosphorodiamidate (I) in aqueous acetone.2) By the Fenton's oxidation (FeSO4,H2O2) of cyclophosphamide (II).3) By ozonization of cyclophosphamide (II) in acetone - water.
📌 参考资料/链接:
参考文献标题:Hydroperoxy substituted cyclic phosphamides
文献作者:Takamizawa,A.; Iwata,T.(Shionogi & Co.Ltd.)
参考来源:DE 2231311; FR 2147956; US 3808297

📄 详细内容


合成路线:This compound can be obtained in three different ways:1) By ozonolysis of 3-butenyl-N,N-bis(2-chloroethyl)phosphorodiamidate (I) in aqueous acetone.2) By the Fenton's oxidation (FeSO4,H2O2) of cyclophosphamide (II).3) By ozonization of cyclophosphamide (II) in acetone - water.

参考文献标题:Cyclophosphamide metabolites and their related compounds.II.Preparatio of an active species of cyclophosphamide and some related compounds
文献作者:Katagiri,K.; Matsumoto,S.; Iwata,T.; Yamaguchi,K.; Tochino,Y.; Takamizawa,A.
参考来源:J Am Chem Soc 1973,95(3),985-986


合成路线:This compound can be obtained in three different ways:1) By ozonolysis of 3-butenyl-N,N-bis(2-chloroethyl)phosphorodiamidate (I) in aqueous acetone.2) By the Fenton's oxidation (FeSO4,H2O2) of cyclophosphamide (II).3) By ozonization of cyclophosphamide (II) in acetone - water.

参考文献标题:Cyclophosphamide metabolites and their related compounds.III.4-Hydrocyclophosphamide anhydro dimer.Revised structure of the Fenton oxidation product of cyclophosphamide
文献作者:Takamizawa,A.; Matsumoto,S.; Iwata,T.
参考来源:Tetrahedron Lett 1974,(6),517-520


合成路线:This compound can be obtained in three different ways:1) By ozonolysis of 3-butenyl-N,N-bis(2-chloroethyl)phosphorodiamidate (I) in aqueous acetone.2) By the Fenton's oxidation (FeSO4,H2O2) of cyclophosphamide (II).3) By ozonization of cyclophosphamide (II) in acetone - water.

参考文献标题:Cyclophosphamide.Complete inhibition of murine leukemia L1210 in vivo by a Fenton oxidation product
文献作者:Laster,W.R.Jr.; Struck,R.F.; Coburn,W.C.Jr.; Thorpe,M.C.
参考来源:J Am Chem Soc 1974,96(1),313-315


合成路线:This compound can be obtained in three different ways:1) By ozonolysis of 3-butenyl-N,N-bis(2-chloroethyl)phosphorodiamidate (I) in aqueous acetone.2) By the Fenton's oxidation (FeSO4,H2O2) of cyclophosphamide (II).3) By ozonization of cyclophosphamide (II) in acetone - water.

参考文献标题:4-Hydroperoxidation in the Fenton oxidation of the antitumor agent cyclophosphamide
文献作者:Van der Steen,J.; Benckhuysen,C.; Westra,J.G.; Timmes,E.C.
参考来源:J Am Chem Soc 1973,95(22),7535-36


合成路线:This compound can be obtained in three different ways:1) By ozonolysis of 3-butenyl-N,N-bis(2-chloroethyl)phosphorodiamidate (I) in aqueous acetone.2) By the Fenton's oxidation (FeSO4,H2O2) of cyclophosphamide (II).3) By ozonization of cyclophosphamide (II) in acetone - water.

参考文献标题:Studies on 4-hydrocyclophosphamide (NSC-181815): A simple preparation method and its application for the synthesis of a new class of "acticvated" sulfur-containing cyclophosphamide (NSC-26271) derivatives
文献作者:Wagner,T.; Hohorst,H.J.; Peter,G.
参考来源:Cancer Treat Rep 1976,60(4),429-435


合成路线:This compound can be obtained in three different ways:1) By ozonolysis of 3-butenyl-N,N-bis(2-chloroethyl)phosphorodiamidate (I) in aqueous acetone.2) By the Fenton's oxidation (FeSO4,H2O2) of cyclophosphamide (II).3) By ozonization of cyclophosphamide (II) in acetone - water.
参考文献标题:4-HPCy
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.; Hopkins,S.J.
参考来源:Drugs Fut 1982,7(7),481


产品链接: CAS No. 62435-42-1››

产品链接: CAS No.39800-16-3››