Unifiram, DM-232
2-[(4-氟苯基)磺酰基]六氢吡咯并[1,2-A]吡嗪-6(2H)-酮Chemical Name: (8aR)-2-(4-Fluorophenylsulfonyl)perhydropyrrolo[1,2-a]pyrazin-6-one
CAS No. 272786-64-8 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Firenze (Originator)
合成路线:Horner-Emmons condensation of 1,4-dibenzyl-2-piperazinecarboxaldehyde (I) with phosphonate (II) gave piperazineacrylate (III).Subsequent double bond hydrogenation and hydrogenolysis of the benzyl groups of (III) produced the spontaneous cyclization of the resulting amino ester to furnish the diazabicyclononanone (IV).Finally,condensation of amine (IV) with p-fluorobenzenesulfonyl chloride (V) yielded the title sulfonamide.
📌 参考资料/链接：
参考文献标题:Design,synthesis,and preliminary pharmacological evaluation of 1,4-diazabicyclo[4.3.0]nonan-9-ones as a new class of highly potent nootropic agents
文献作者:Manetti,D.; Ghelardini,C.; Bartolini,A.; Bellucci,C.; Dei,S.; Galeotti,N.; Gualtieri,F.; Romanelli,M.N.; Scapecchi,S.; Teodori,E.
参考来源:J Med Chem 2000,43(10),1969