VP-14637

2,2'-(4-羟基苯亚甲基)二[4-(5-甲基-1H-四唑-1-基亚氨基甲基)苯酚]Chemical Name: 2,2'-(4-Hydroxybenzylidene)bis[4-(5-methyl-1H-tetrazol-1-yliminomethyl)phenol]
CAS No. 235106-62-4
项目整合开发状态: Discontinued
项目研究机构: ViroPharma (Originator)
合成路线:3-Bromo-4-hydroxybenzaldehyde (I) was protected as the corresponding cyclic ketal (III) by treatment with neopentyl glycol (II) and pyridinium p-toluenesulfonate.Lithiation of (III) with n-butyllithium,followed by addition to methyl 4-methoxybenzoate (IV),furnished the triaryl carbinol (V).Deketalization of (V) with concomitant reduction of the tertiary alcohol to yield (VI) was accomplished upon heating in formic acid.Subsequent cleavage of the methoxy groups of (VI) by means of boron tribromide afforded the trihydroxy derivative (VII).Finally,dialdehyde (VII) was condensed with 1-amino-5-methyltetrazole (VIII) to generate the title bis-imine.